Nasal Mucosal Hemodynamics in Nasal Allergy.

Mechanisms of the Development of Nasal Hyperreactivity in Nasal Allergy

Nasal hyperreactivity in nasal allergy conditions is closely related to allergic inflammation, particularly to infiltration by activated eosinophils in the nasal mucosa, observed 4 to 10 hours after a single antigenic challenge. Repeated antigenic challenge in subjects with nasal allergy enhanced nasal hyperreactivity. On the other hand, various therapies including topical steroids, immunothera...

The Nasal Smear for Eosinophils, Its Value, and Its Relation to Nasal Mucosal Eosinophilia in Allergic Rhinitis

Introduction: There is no single test as a gold standard for the diagnosis of allergic rhinitis (AR). The aim of this study was to assess the usefulness and validity of nasal smear as a quick, easy and inexpensive diagnostic method for diagnosis of allergic rhinitis. Materials and Methods: This study was conducted in a university hospital setting. Nasal smears were taken from 39 patients wit...

Absence of nasal mucosal atrophy with fluticasone aqueous nasal spray.

OBJECTIVE To evaluate whether 1 year of continuous treatment with intranasal fluticasone propionate would lead to atrophy in the nasal mucosa compared with an active control, oral terfenadine. DESIGN Prospective, randomized, multicenter, open-label, parallel-group study. SETTING Two tertiary care academic institutions. PATIENTS Seventy-five subjects older than 18 years with perennial alle...

Nasal allergy: milestones in understanding the disease.

Tumour necrosis factor-α in nasal allergy

Tumour necrosis factor-alpha (TNF-alpha) was measured by enzyme-linked immunosorbent assay and eosinophil cationic protein (ECP) by radio-immunoassay to evaluate TNF-alpha in nasal allergy. There was no significant difference either between the mean concentrations of TNF-alpha in nasal secretions from the patients with perennial nasal allergy and those of normal subjects, or between the TNF-alp...